Basic information 

Name

NGUYEN HOANG LOC

Position

Professor  and Director of Institute of Bioactive Compounds, College of Sciences, Hue University, Hue, Vietnam

Year of Birth

1962

Major

Biotechnology 

1984

BSc, Hue University, Vietnam 

1992

PhD, Institute of Biotechnology, Vietnam Academy of Science and Technology

1995-1997       

Postdoc (STA Fellowship), National Institute of Agrobiological Sciences,

Tsukuba, Japan

2000-2003

Postdoc (BK21 Program), Chonbuk National University, Jeonju, South Korea

2003-2013

Associate Professor, Hue University, Vietnam

2013 to present

Professor, Hue University, Vietnam

Contact 

E-mail: nhloc@hueuni.edu.vn / nhlocs@gmail.com

Phone: +84-234-6505051

Fax: +84-234-3824901 

Editorial board member of journals (SCIE)

- Pharmacognosy Magazine

- Asian Pacific Journal of Tropical Biomedicine 

Research interests

- Heterologous enzyme production in yeast and bacteria.

- Expression of genes coding subunit antigens in plants and bacteria.

- Regulation of gene expression in the pathways of secondary metabolism in plant cells.

Leader of research projects

1. Ministry of Education and Training, VN (B94-06-04): Application of plant cell biotechnology for micropropagation of valuable ornamental flowering plants.

2. Basic Research Program in Natural Science, VN (KT04-05-03-33): Micropropagation of some valuable tree plants.

3. Basic Research Program in Natural Science, VN (6-3-13/20): Selection of high drought-tolerant sugarcane cell lines.
4. Ministry of Education and Training, VN (B2004-07): Micropropagation of Solanum hainanense Hance-a valuable medicinal plant.
5. Basic Research Program in Natural Science, VN (64-21-04): Introduction of CTB gene into plants through Agrobacterium tumefaciens-meditaed transformation.
6. Ministry of Education and Training, VN (extention of B2004-07): Extraction of total glycoalkaloid from Solanum hainanense Hance callus.
7. Basic Research Program in Natural Science, VN (61-60-06): Recovery of some bioactive compounds from zedoary (Curcuma zedoaria Roscoe) cells cultured in bioreactor.
8. Korea Foundation for Advanced Studies-Ha Noi National University, VN (2007-2009): Cloning and expression of protease gene from Bacillus subtilis.
9. Higher Education Project, VN (
KH04-DAGD2): Introduction of LTB gene into plants and analyse its expression level.
10. Ministry of Education and Training, VN (B2009-DHH08): Cloning and expression of chitinase gene against fungal pathogens in plants.
11. Thua Thien Hue Province, VN (TTH.2009-KC.06UTCN): Production of recombinant protease in pilot scale and application for soybean sauce processing.

12. Ministry of Science and Technology, VN (2011-2013): Making recombinant adherent antigen for production of diagnostic kit and diarrhea vaccine of pig.

13. Thua Thien Hue Province, VN (2012-2013): Cloning and expression of genes encoding glucanase in yeast.

14. Ministry of Education and Training, VN (B2012-DHH-59): Production of recombinant chitinase in pilot scale.

15. National Foundation for Science & Technology Development (NAFOSTED), VN (2013-2016): Investigation into salicylic acid elicitation and regulation of gene expression in centelloside biosynthetic pathway in cell cultures of centella (Centella asiatica (L.) Urban).

16. Thua Thien Hue Province, VN (2016-2018): Isolation of dibenzofuran degrading bacteria from dioxin contaminated soil in A Luoi district, Thua Thien Hue province.

17. National Foundation for Science & Technology Development (NAFOSTED), VN (2017-2020): Expression of chitinase gene (chi42) from Trichoderma asperellum in peatnut (Arachis hypogeae) to enhance resistance to white mold disease caused by Sclerotium rolfsii.

Publications

A. International journals

See more: Google Scholar - ResearchGate - ORCID

1. Tae-Jin Kang, Jo-Eun Seo, Nguyen-Hoang Loc, Moon-Sik Yang (2003) Herbicide resistance of tobacco chloroplast expressing the bar gene. Molecules and Cells 16(1): 60-66.

2. Tae-Jin Kang, Tae-Ho Kwon, Tae-Gum Kim, Nguyen-Hoang Loc, Moon-Sik Yang (2003) Comparing constitutive promoters using CAT activity in transgenic tobacco plants. Molecules and Cells 16(1): 117-122.

3. Tae-Jin Kang, Nguyen-Hoang Loc, Mi-Ok Jang, Yong-Suk Jang, Young-Sook Kim, Jo-Eun Seo, Moon-Sik Yang (2003) Expression of the B subunit of E. coli heat-labile enterotoxin in the chloroplasts of plants and its characterization. Transgenic Research 12(6): 683-691.

4. Tae-Jin Kang, Nguyen-Hoang Loc, Mi-Ok Jang, Moon-Sik Yang (2004) Modification of the cholera toxin B subunit coding sequence to enhance expression in plants. Molecular Breeding 13(2): 143-153.

5. Jae-Hwa Lee, Nguyen-Hoang Loc, Tae-Ho Kwon, Moon-Sik Yang (2004) Partioning of recombinant human granulocyte-macrophage colony stimulating factor from plant cell suspension culture in PEG/sodium phosphate aqueous two-phase system. Biotechnology and Bioprocess Engineering 9(1): 12-16.

6. Nguyen Hoang Loc, Doan Trong Duc, Tae Ho Kwon, Moon Sik Yang (2005) Micropropagation of zedoary (Curcuma zedoaria Roscoe)-a valuable medicinal plant. Plant Cell, Tissue and Organ Culture 81(1): 119-122.

7. Nguyen Hoang Loc, Doan Thi Hong Diem, Doan Huu Nhat Binh, Dao Thi Huong, Tae Geum Kim, Moon Sik Yang (2008) Isolation and characterization of antioxidation enzymes from cells of zedoary (Curcuma zedoaria Roscoe) cultured in a 5-L bioreactor. Molecular Biotechnology 38(1): 81-87.

8. Nguyen Hoang Loc, Vo Chau Tuan, Doan Huu Nhat Binh, Truong Thi Bich Phuong, Tae Geum Kim, Moon Sik Yang (2009) Investigation on the accumulation of sesquiterpenes and polysaccharide from cells of zedoary (Curcuma zedoaria Roscoe) cultured in a 10-L bioreactor. Biotechnology and Bioprocess Engineering 14: 619-624. 

9. Nguyen Hoang Loc, Nguyen Hoang Bach, Tae-Geum Kim, Moon-Sik Yang (2010) Tissue culture and expression of Escherichia coli heat-labile enterotoxin B subunit in transgenic Peperomia pellucida. Protein Expression and Purification 72: 82-86. 

10. Nguyen Hoang Loc, Nguyen Huu Thuan Anh, Doan Huu Nhat Binh, Moon-Sik Yang, Tae-Geum Kim (2010) Production of glycoalkaloids from callus cultures of Solanum hainanense Hance. Journal of Plant Biotechnology 37: 96-101.

11. Nguyen Hoang Loc, Nguyen Thi Thuy Mien, Do Thi Bich Thuy (2010) Purification of extracellular α-amylase from Bacillus subtilis by partitioning in polyethylene glycol/potassium phosphate aqueous two-phase system. Annals of Microbiology 60: 623-628.

12. Nguyen Hoang Loc, Nguyen Thi Tam An (2010) Asiaticoside production from cell culture of centella (Centella asiatica L. Urban). Biotechnology and Bioprocess Engineering 15: 1065-1070.

13. Nguyen Hoang Loc, Nguyen Van Song, Nguyen Quang Duc Tien, Tang Thuy Minh, Phan Thi Quynh Nga, Tae-Geum Kim, Moon-Sik Yang (2011) Expression of the Escherichia coli heat-labile enterotoxin B subunit in transgenic watercress (Nasturtium officinale L.). Plant Cell, Tissue and Organ Culture 105: 39-45.

14. Nguyen Hoang Loc, Huynh Van Kiet (2011) Micropropagation of Solanum hainanense Hance. Annals of Biological Research 2(2): 394-398.

15. Nguyen Hoang Loc, Le Thi Thinh, Moon-Sik Yang, Tae-Geum Kim (2011) High expression of cholera toxin B subunit in transgenic tomato (Lycopersicon esculentum L.) fruits. Biotechnology and Bioprocess Engineering 16: 576-580.

16. Nguyen Hoang Loc, Le Thi Ha Thanh (2011) Solasodine production from cell culture of Solanum hainanense Hance. Biotechnology and Bioprocess Engineering 16: 581-586.

17. Nguyen Hoang Loc, Hoang Tan Quang, Bui Thi Hong Lam, Dao Thi Thuy Trang (2011) The effects of culture conditions on neutral protease (NPRC10) in a recombinant Escherichia coli BL21 (DE3). Annals of Biological Research 2(3): 474-485.

18. Nguyen Hoang Loc, Hoang Tan Quang, Nguyen Bao Hung, Nguyen Duc Huy, Truong Thi Bich Phuong, Tran Thi Thu Ha (2011) Trichoderma asperellum chi42 genes encode chitinase. Mycobiology 39(3): 182-186.

19. Hoang Tan Quang, Le Thi Xuan, Ngo Thi Mai, Nguyen Van Trung, Nguyen Thi Thu Lien, Truong Thi Bich Phuong, Nguyen Hoang Loc (2011) Genetic variability of "Thanh tra" pummelo (Citrus grandis Osbeck) in Thua Thien Hue, Vietnam. Annals of Biological Research 2(4): 306-314.

20. Nguyen Hoang Loc, Do Van Giap, Hoang Tan Quang (2011) Production of NPRC10 protease by recombinant Escherichia coli through submerged culture in 40-L fermenter. Annals of Biological Research 2(6): 62-68.

21. Nguyen Hoang Loc, Nguyen Thanh Giang (2012) Effects of elicitors on the enhancement of asiaticoside biosynthesis in cell cultures of centella (Centella asiatica L. Urban). Chemical Papers 66(7): 642-648.

22. Nguyen Hoang Loc, Dang Thanh Long, Phan Y Nhi, Hoang Thi Kim Hong, Tae-Geum Kim, Moon-Sik Yang (2012) Preliminary evaluation of transgenic tomato plants expressing Escherichia coli heat-labile toxin B subunit grown under in vivo condition. Annals of Biological Research 3(5): 2070-2073.

23. Nguyen Hoang Loc, Nguyen Sy Cong, Do Van Giap, Nguyen Thi Quy Hoa, Hoang Tan Quang, Nguyen Duc Huy (2012) Production of recombinant NPRC10 protease in 14-L fermentation scale. European Journal of Experimental Biology 2(4): 913-918.

24. Nguyen Hoang Loc, Le My Tieu Ngoc, Tran Thuy Lan, Le Quoc Viet, Le Duc Thao, Hoang Tan Quang, Dinh Thi Bich Lan, Phung Thang Long (2013) Cloning and expression of genes encoding F107-C and K88-1NT fimbrial proteins of enterotoxigenic Escherichia coli from piglets. Indian Journal of Microbiology 53(4): 488-491.

25. Nguyen Hoang Loc, Ho Thi Thu Lien, Do Van Giap, Hoang Tan Quang (2013) Purification of recombinant neutral protease (NPRC10) by partitioning in aqueous two-phase systems. European Journal of Experimental Biology 3(2): 252-257.

26. Nguyen Hoang Loc, Nguyen Thi Duy Nhat (2013) Production of asiaticoside from centella (Centella asiatica L. Urban) cells in bioreactor. Asian Pacific Journal of Tropical Biomedicine 3(10): 806-810.

27. Nguyen Hoang Loc, Nguyen Thi Quy Hoa, Pham Thi Kim Cuc, Hoang Tan Quang (2013) Expression of chitinase (chi42) gene from Trichoderma asperellum in Saccharomyces cerevisiae. Annals of Biological Research 4(9):15-19.

28. Nguyen Hoang Loc, Nguyen Huu Thuan Anh, Le Thi Minh Khuyen, Ton Nu Thuy An (2014) Effects of yeast extract and methyl jasmonate on the enhancement of solasodine biosynthesis in cell cultures of Solanum hainanense Hance. Journal of BioScience and Biotechnology 3(1): 1-6.

29. Nguyen Hoang Loc, Dang Thanh Long, Tae-Geum Kim, Moon-Sik Yang (2014) Expression of Escherichia coli heat-labile enterotoxin B subunit in transgenic tomato (Lycopersicon esculentum L.) fruit. Czech Journal of Genetics and Plant Breeding 50(1): 26-31. 

30. Dinh Thi Bich Lan, Tran Thuy Lan, Le Quoc Viet, Phan Van Quyet, Hoang Tan Quang, Nguyen Hoang Loc, Phung Thang Long (2014) Cloning and expression of gene encoding P23 protein from Cryptosporidium parvum. Journal of BioScience and Biotechnology 3(3): 189-193.

31. Nguyen Hoang Loc, Nguyen Van Song, Dang Thanh Long, Tae-Geum Kim, Moon-Sik Yang (2015) In vivo evaluation of transgenic watercress containing gene encoding Escherichia coli heat-labile toxin B subunit. Journal of Plant Biochemistry and Biotechnology 24(2): 129-134.

32. Nguyen Hoang Loc, Le My Tieu Ngoc, Doan Thi Tam, Tran Thuy Lan, Dinh Thi Bich Lan, Phung Thang Long (2015)Cloning and expression of gene FanC-2NT encoding K99-2NT fimbrial antigen of  enterotoxigenic Escherichia coli  from diarrheic post-weaning piglets. Periodicum Biologorum 117(3): 435-440. 

33. Nguyen Duc Huy, Cu Le Nguyen, Han-Sung Park, Nguyen Hoang Loc, Myoung-Suk Choi, Dae-Hyuk Kim, Jeong-Woo Seo, Seung-Moon Park (2016) Characterization of a novel manganese dependent endoglucanase belongs in GH family 5 from Phanerochaete chrysosporium. Journal of Bioscience and Bioengineering 121(2): 154-159.

34. Nguyen Hoang Loc, Le My Tieu Ngoc, Hoang Tan Quang, Nguyen Duc Huy, Nguyen Ngoc Luong (2016) Cloning and expression of two genes encoding for endo-β-1,4-glucanase from Trichoderma asperellum PQ34 in Pichia pastoris. Chemical Papers 70(3): 284-293. 

35. Nguyen Huu Thuan Anh, Ton Nu Thuy An, Nguyen Thuan Nho, Vo Thi Vien Dung, Nguyen Hoang Loc (2016) Effect of salicylic acid on the biosynthesis of solasodine in cell suspension culture of Solanum hainanense Hance. Plant Cell Biotechnology and Molecular Biology 17(1-2): 14-20.

36. Nguyen Thanh Giang, Nguyen Duc Huy, Le Thi Ha Thanh, Nguyen Hoang Loc (2016) Efficiency of the combination of salicylic acid, yeast extract and methyl jasmonate on asiaticoside production in centella (Centella asiatica (L.) Urban) cells. Plant Cell Biotechnology and Molecular Biology 17(1-2): 64-71.

37. Nguyen Hoang Loc, Nguyen Thanh Giang, Nguyen Duc Huy (2016) Effect of salicylic acid on expression level of genes related with isoprenoid pathway in centella (Centella asiatica (L.) Urban) cells. 3 Biotech 6: 86. https://doi.org/10.1007/s13205-016-0404-z.

38. Nguyen Hoang Loc, Pham Thi Ngoc Lan, Le Thi Ha Thanh et al (2016) An investigation on the distribution and genetic diversity of Eurycoma longifolia Jack, and in vitro conservation of this valuable medicinal tree in Thua Thien Hue, Vietnam. Plant Cell Biotechnology and Molecular Biology 17(5-6): 226-234.   

39. Nguyen Hoang Loc, Nguyen Thanh Giang, Nguyen Duc Huy, Truong Thi Phuong Lan (2017) Accumulation of madecassoside - a major component of centelloside - in centella (Centella asiatica (L.) Urban) cells elicited by salicylic acid. Periodicum Biologorum 119(1): 81-85.

40. Nguyen Huu Nhan, Nguyen Hoang Loc (2017) Production of eurycomanone from cell suspension culture of Eurycoma longifolia Jack. Pharmaceutical Biology 55(1): 2234-2239.

41. Hoang Thanh Tung, Nguyen Ba Nam, Nguyen Phuc Huy, Vu Quoc Luan, Vu Thi Hien, Le Tien Dung, Truong Thi Bich Phuong, Nguyen Hoang Loc, Duong Tan Nhut (2018) A system for large scale production of chrysanthemum using microponics with the supplement of silver nanoparticles under light-emitting diodes. Scientia Horticulturae 232(17): 153-161.

42. Nguyen Thi Anh Thu, Ngo Thi Tuong Chau, Le Van Thien, Nguyen Duc Huy, Nguyen Tran Me Khue, Nguyen Bao Hung, Nguyen Ngoc Luong, Le Thi Anh Thu, Nguyen Hoang Loc (2018) Extra-chromosomal expression of nat05 gene encoding an alkaline serine protease from Bacillus subtilis N05. Biotechnologia (in press).

43. Nguyen Hoang Loc, Pham Thi Ngoc Lan, Van Thi Yen, Hoang Trong Dat (2018) Some physiological and biochemical characteristics of Eurycoma longifolia Jack tree grown in the arboretum. Plant Cell Biotechnology and Molecular Biology 19(5&6): 249-255.

44. Truong Thi Phuong Lan, Nguyen Duc Huy, Nguyen Ngoc Luong, Nguyen Van Nghi, Trinh Huu Tan, Le Viet Quan, Nguyen Hoang Loc (2018) Identification and characterization of genes in curcuminoid pathway of Curcuma zedoaria Roscoe. Current Pharmaceutical Biotechnology. DOI: 10.2174/1389201019666181008112244.

45. Nguyen Huu Nhan, Nguyen Hoang Loc (2018) Enhancement of eurycomanone biosynthesis in cell culture of longjack (Eurycoma longifolia) by elicitor treatment. Journal of Plant Biotechnology (in press).

B. Domestic journals

1. Nguyen Hoang Loc, Le Tran Binh, Le Thi Muoi (1990) Selection of NaCl-tolerant tobacco lines from diploid and haploid callus cultures. Vietnam J Biol 12(3): 7-15.
2. Nguyen Hoang Loc, Le Tran Binh, Le Thi Muoi (1991) Desiccation and salt stresses stimulate growth and regeneration ofCraterostigma plantagineum Hochst in in vitro culture. Proc NCSR Vietnam 3: 92-99.

3. Nguyen Hoang Loc, Le Tran Binh, Le Thi Muoi (1992) Osmotic adjustment of tobacco callus. Proc NCSR Vietnam 4(2): 73-80.
4. Nguyen Hoang Loc, Le Tran Binh, Le Thi Muoi, Hoang Thi Tuyet Ngoc (1992) Study of desiccation tolerant ability of tobacco callus in in vitro culture. Vietnam J Biol 14(1): 31-37.
5. Nguyen Hoang Loc, Tran Thanh Thu, Le Thi Muoi, Le Tran Binh (1992) Modifications of biochemical properties of NaCl-tolerant and desiccation-tolerant tobacco lines in in vitro culture. Vietnam J Genet Appl 1: 35-39.
6. Nguyen Hoang Loc, Tran Thanh Thu, Le Tran Binh, Le Thi Muoi (1994) The analysis of NaCl-tolerant stability in selected tobacco lines. Proc NCST Vietnam 6(1): 47-56.

7. Nguyen Hoang Loc, Ngo Anh, Tran Thien An (1997) Study on the micropropagation of Aquilaria crassna Pierre. Vietnam J Biol 19(4): 49-50.
8. Nguyen Hoang Loc, Hoang Thi Kim Hong (1998) Micropropagation of Hippeastrum reticulatum by axillary bud and bulb scale culture. Proc NTSC Vietnam 10(2): 85-89.
9. Mai Van Pho, Nguyen Hoang Loc (1998) The diversity of the species composition on orchid family (Orchidaceae Juss.) living in Bach Ma National Park. Vietnam J Biol 20(2): 33-37. 
10. Nguyen Hoang Loc, Mai Van Pho (1998) Micropropagation of Aerides odorata orchid plant. Vietnam J Biol 20(2): 41-43.
11. Nguyen Hoang Loc, Le Van Tuong Huan (1998) Induction of polyploid Allium fistulosum plants by callus culture. Vietnam J Biol 20(2): 44-48.
12. Nguyen Hoang Loc (1998) Gene transformation technology in higher plants (review). Vietnam J Biol 20(2): 7-14.
13. Nguyen Hoang Loc, Akihiro Suzuki, Fumio Takaiwa (1999) Molecular cloning and expression of myb-related genes in rice seed. Proc National Biotechnology Conference, Sci and Tech Publishing House, Ha Noi, Vietnam 1266-1273.
14. Nguyen Hoang Loc, Vo Chau Tuan, Le Thi Thinh, Cao Dang Nguyen (2000) Effect of mannitol on the dynamic of lectin accumulation in rice (Oryza sativa L.) callus cultures. Vietnam J Biol 22(3b): 92-95.
15. Nguyen Hoang Loc, Vo Chau Tuan, Phan Cong Binh, Le Thi Thinh (2000) Effects of mannitol on proline and glucose accumulation in relation to osmotic adjustment in rice (Oryza sativa L.) callus cultures. Vietnam J Biol 22(3b): 96-100.
16. Nguyen Hoang Loc, Mai Van Pho (2000) Preliminary data on the Orchidaceae in Thua Thien Hue and in vitropreservative studies for some species of this family. Vietnam J Biol 22(3b): 173-178.

17. Nguyen Hoang Loc (2000) Gene transfer and applications in gene therapy. Vietnam J Biol 22(3b): 82-91.
18. Truong Thi Bich Phuong, Huynh Van Kiet, Nguyen Hoang Loc, Nguyen Huu Dong (2000) Effect of mannitol on the change of cell structure in rice (Oryza sativa L.) callus cultures. Vietnam J Genet Appl 3: 13-20.
19. Nguyen Hoang Loc, Ngo Anh, Doan Nhan Ai, Vuong Quang Man, Dang Quang Bang (2001) Propagation of Camellia japonica by cutting. Vietnam J Biol 23(2): 39-44.
20. Truong Thi Bich Phuong, Ton Nu Gia Ai, Nguyen Hoang Loc, Nguyen Huu Dong (2002) Selection of drought-tolerant lines of rice (Oryza sativa L.). Vietnam J Agriculture and Rural Development 7: 579-580.

21. Nguyen Hoang Loc, Truong Thi Bich Phuong, Truong Thi Phuong Lan, Dang Thi Thu Thuy, Nguyen Huu Dong (2002) Effect of mannitol on proline and glucose accumulation in relation to osmotic adjustment in sugarcane (Saccharum officinarum L.). Vietnam J Agriculture and Rural Development 8: 664-666.

22. Tae-Jin Kang, Nguyen-Hoang Loc, Jo-Eun Seo, Moon-Sik Yang (2002) High level of herbicide tolerance by the expression of bar gene in the chloroplast of tobacco plant. Proc. Current Biotechnology and Bioengineering (XI-B), Korea 921-924.

23. Nguyen Hoang Loc, Tae-Gum Kim, Seung-Moon Park, Tae-Ho Kwon, Dae-Huyk Kim, Moon-Sik Yang (2003) Ordered differential display of mRNA from Nicotiana tabacum. Advances in Natural Sciences 4(4): 331-338.

24. Nguyen Hoang Loc, Truong Thi Bich Phuong, Dang Thi Thu Thuy, Nguyen Huu Dong (2003) Selection of drought-tolerant lines of sugarcane (Saccharum officinarum L.). Vietnam J Biol 25(1A): 112-118.
25. Truong Thi Bich Phuong, Ngo Thi Hong Phuong, Nguyen Hoang Loc, Nguyen Huu Dong (2003) Osmotic adjustment of rice callus. Vietnam J Agriculture and Rural Development 4: 414-416.
26. Truong Thi Bich Phuong, Hoang Tan Quang, Nguyen Hoang Loc, Nguyen Huu Dong (2003) Morphological characters of some rice (Oryza sativa L.) varieties cultivated from gamma ray (60Co) treated seed in M2. Proc the 2nd National Conference in Life Science, Sci and Tech Publishing House, Ha Noi, Vietnam 706-708.
27. Truong Thi Bich Phuong, Nguyen Hoang Loc, Nguyen Huu Dong (2003) Structural changes of drought tolerant rice (Oryza sativa L.) cell selected from gamma ray (60Co) treated callus culture. Proc National Biotechnology Conference, Sci and Tech Publishing House, Ha Noi, Vietnam 944-948.
28. Nguyen Hoang Loc, Truong Thi Bich Phuong, Le Quoc Phong (2004) Development of regeneration system in banana through culture of embryogenic callus. Proc the 2004th National Conference on Life Sciences, Sci and Tech Publishing House, Ha Noi, Vietnam 479-481.
29. Truong Thi Bich Phuong, Nguyen Thi Duy Khoa, Nguyen Hoang Loc, Tran Thi Han, Nguyen Thi Thanh, Nguyen Van Hue (2004) Micropropagation of Xanthosoma nigrum. Proc the 2004th National Conference on Life Sciences, Sci and Tech Publishing House, Ha Noi, Vietnam 575-578.
30. Huynh Van Kiet, Cao Dang Nguyen, Nguyen Hoang Loc (2005) Effects of some plant growth regulators on in vitroregeneration of Solanum hainanense plant. Proc the 2005th National Conference on Life Sciences, Sci and Tech Publishing House, Ha Noi, Vietnam 602-605.
31. Nguyen Hoang Loc, Le Thi Thinh, Nguyen Van Song, Tae-Jin Kang, Moon-Sik Yang (2005) Transformation of cholera toxin B subunit gene into sugarcane mediated by Agrobacterium tumefaciens. Proc the 2005th National Conference on Life Sciences, Sci and Tech Publishing House, Ha Noi, Vietnam 1292-1294.
32. Truong Thi Bich Phuong, Nguyen Van Song, Nguyen Hoang Loc (2005) Analysis of SDS-PAGE of seed proteins and drough-tolerant gene sequence of some in vitro selected rice lines. Proc the 2005th National Conference on Life Sciences, Sci and Tech Publishing House, Ha Noi, Vietnam 1358-1361.
33. Nguyen Hoang Loc, Tran Thi Trieu Ha, Yutaka Hirata (2006) Effect of several factors on cell biomass production of zedoary (Curcuma zedoaria Roscoe) in bioreactor. Vietnam J Biotechno l 4(2): 213-220.
34. Nguyen Huu Thuan Anh, Le Thi Ha Thanh, Doan Huu Nhat Binh, Truong Thi Bich Phuong, Nguyen Hoang Loc (2007) Study on the accumulation of glycoalkaloid in Solanum hainanense Hance callus. Proc the 2007th National Conference on Life Sciences, Sci and Tech Publishing House, Ha Noi, Vietnam 229-232.

35. Ha Thi Minh Thi, Nguyen Viet Nhan, Trinh Van Bao, Tran Thi Thanh Huong, Nguyen Hoang Loc (2007) Completion of PCR technique for screening the FMR1 gene mutation in mental retardation. Vietnam J Prac Med 1(562): 59-63.

36. Truong Thi Bich Phuong, Duong Thi Thao Trang, Nguyen Van Song, Nguyen Hoang Loc (2008) Determining blast resistance gene pi-b in some rice (Oryza sativa L.) cultivars. Vietnam J Biotechnol 6(1): 61-68. 
37. Nguyen Hoang Loc, Truong Thi Bich Phuong, Nguyen Van Song, Phan Thi Phuong Nhi, Truong Thi Tram Chi, Duong Thi Thao Trang (2008) Determining blast resistance gene pi-ta in some rice (Oryza sativa L.) cultivars by PCR technique. Vietnam J Biotechnol 6(2): 221-226. 
38. Nguyen Hoang Loc, Luu Thi Nguyet Minh, Do Thi Bich Thuy (2008) Partitioning of extracellular protease from Bacillus subtilis in PEG/potassium phosphate aqueous two-phase systems. Vietnam J Biotechnol 6(3): 375-382.
39. Hoang Tan Quang, Nguyen Duc Huy, Truong Thi Bich Phuong, Nguyen Hoang Loc (2008) Two dimensional electrophoresis of protein in drought-tolerant rice (Oryza sativa L.) lines selected from in vitro cultures. Vietnam J Biotechnol 6(4): 439-443. 
40. Nguyen Hoang Loc, Doan Huu Nhat Binh, Phan Duc Lam, Phan Thi A Kim, Truong Thi Bich Phuong (2008) Study on the accumulation of asiaticoside in callus of Centella asiatica (L.) Urban. Vietnam J Biotechnol 6(4B): 873-881.
41. Truong Thi Bich Phuong, Tran Thi Kim Thu, Nguyen Hoang Loc (2008) Micropropagation of Polygonum multiflorumThumb. Vietnam J Biotechnol 6(4B): 889-895.
42. Nguyen Hoang Loc, Nguyen Van Song, Hoang Tan Quang, Le Duc Dung, Duong Duc Loi, Truong Thi Bich Phuong, Do Thi Bich Thuy (2008) Cloning and expression of neutral protease gene from Bacillus subtilis. Vietnam J Biotechnol 6(4B): 963-970.

43. Ha Thi Minh Thi, Nguyen Viet Nhan, Tran Thi Thanh Huong, Nguyen Hoang Loc (2008) Appication of techniques of molecular biology in diagnosis of fragile X syndrome. Vietnam J Medical Research 58: 18-23.

44. Nguyen Hoang Loc, Phan Thi A Kim, Nguyen Hoang Bach, Truong Thi Bich Phuong, Tae-Geum Kim, Tae-Jin Kang, Moon-Sik Yang (2009) Expression of ltb (Escherichia coli heat-labile enterotoxin B subunit) in centella (Centella asiatica (L.) Urban). Proc the National Conference for Genetically Modified Organism and Biosafety Management. Natural Sciences and Technology Publishing House, Ha Noi 89-95.
45. Le Thi Ha Thanh, Doan Huu Nhat Binh, Nguyen Hoang Loc (2009) Production of glycoalkaloid from cells of Solanum hainanense Hance. Proc the National Conference of Biotechnology. Natural Sciences and Technology Publishing House, Ha Noi 697-700.

46. Dinh Thi Bich Lan, Phung Thang Long, Nguyen Hoang Loc, Giang Thanh Nha, Nguyen Quang Vinh, Tran Thuy Lan (2009) Research on producing dipstick for rapid diagnosis of human and animal Toxoplasmosis. Vietnam J Vet Sci Technol XVI (6): 56-61.
47. Hoang Tan Quang, Nguyen Thi Thu Hien, Nguyen Thi Thu Lien, Truong Thi Bich Phuong, Nguyen Hoang Loc (2010) Genetic variation of Thanh tra pummelo (Citrus grandis (L.) Osbeck) at Huong Tra, Thua Thien Hue. Vietnam J Biotechnol 8(2): 213-220.

48. Nguyen Hoang Loc, Nguyen Thi Tam An (2010) Effect of culture medium on the growth and asiaticosdie accumulation of centella (Centella asiatica L. ) cells. Vietnam J Biotechnol 8(3A): 517-522.

49. Nguyen Hoang Loc, Nguyen Van Song, Nguyen Quang Duc Tien, Tang Thuy Minh, Pham Thi Quynh Nga, Truong Thi Bich Phuong, Kim Tae-Geum, Yang Moon-Sik (2010) Expression of heat-labile enterotoxin B subunit from Escherichia coli in transgenic watercress (Nasturtium officinale L.). Vietnam J Biotechnol 8(3B): 1173-1179. 

50. Nguyen Van Song, Nguyen Quang Duc Tien, Tang Thuy Minh, Pham Thi Quynh Nga, Nguyen Hoang Loc (2010) Development of in vitro regeneration system in watercress (Nasturtium officinale L.). Vietnam J Biotechnol 8(3B): 1181-1184.  

51. Le Thi Thinh, Tae-Geum Kim, Moon-Sik Yang, Nguyen Hoang Loc (2010) Study of growth and development of CTB (cholera toxin B subunit) transgenic tomato. Vietnam J Biotechnol 8(3B): 1271-1278. 

52. Phan Y Nhi, Tae-Geum Kim, Moon-Sik Yang, Nguyen Hoang Loc (2010) Expression of Escherichia coli heat-labile enterotoxin B subunit in transgenic tomato (Lycopersicon esculentum L.).  Vietnam J Biotechnol 8(3B): 1279-1285. 

53. Hoang Tan Quang, Hoang Thi Ai Van, Nguyen Van Trung, Truong Thi Bich Phuong, Nguyen Hoang Loc (2010) Genetic variability of "Thanh tra" pummelo (Citrus grandis Osbeck) in Hue, Vietnam. Vietnam J Biotechnol 8(3B): 1333-1341. 

54. Vo Chau Tuan, Nguyen Hoang Loc (2010) Production of curcumin from zedoary (Curcuma zedoaria Roscoe) cells cultured in 10-liter bioreactor. Vietnam J Biotechnol 8(3B): 1459-1464. 

55. Nguyen Thi Phuc Loc, Vo Chau Tuan, Nguyen Hoang Loc (2010) Investigation on antibacterial activity of essential oil extracted from zedoary (Curcuma zedoaria Roscoe) cells cultured in 10-liter bioreactor. Vietnam J Biotechnol 8(3B): 1465-1471. 

56. Nguyen Bao Hung, Hoang Tan Quang, Tran Thi Thu Ha, Tran Nguyen Thao, Tran Thi Diem Chau, Nguyen Hoang Loc(2010) Isolation and characterization of 42 kDa chitinase from Trichoderma asperellum. Vietnam J Biotechnol 8(3B): 1651-1657. 

57. Le Thi Thinh, Tae-Geum Kim, Moon-Sik Yang, Nguyen Hoang Loc (2010) Expression of CTB (cholera toxin B subunit) in tomato (Lycopersicon esculentum L.). Vietnam J Biotechnol 8(4): 1853-1858.

58. Vo Chau Tuan, Vu Duc Hoang, Nguyen Hoang Loc (2011) Cell suspension culture of zedoary (Curcuma zedoariaRoscoe. VNU Journal of Science. Natural Sciences and Technology 27: 64-70.

59. Hoang Tan Quang, Pham Thi Thanh Phuong, Nguyen Van Trung, Truong Thi Bich Phuong, Nguyen Hoang Loc (2011)Morphological, growth and development characteristics of Thanh tra pomelo (Citrus grandis (L.) Osbeck) at diffirent areas of Thua Thien Hue province. Proc the 4th National Scientific Conference on Ecology and Biological Resources. Agri Publishing House, Hanoi, Vietnam 1269-1275.

60. Hoang Tan Quang, Nguyen Van Trung, Hoang Thi Ai Van, Le Thi Xuan, Ngo Thi Mai, Nguyen Thi Thu Lien, Truong Thi Bich Phuong, Nguyen Hoang Loc (2011) Study on genetic diversity of Thanh tra pummelo (Citrus grandis (L.) Osbeck) at Thua Thien Hue. Vietnam J Biotechnol 9(4A): 681-688.

61. Cu Le Nguyen, Tran Nguyen Thao, Nguyen Duc Huy, Hoang Tan Quang, Nghiem Van Tung, Nguyen Hoang Loc (2012) Characterization of extracellular protease from Bacillus pumilus I7. Vietnam J Biotechnol 10(4A): 825-831.

62. Nguyen Hoang Loc, La Phuong Thao, Hoang Tan Quang, Nguyen Thi Quy Hoa, Nguyen Thanh Giang (2012) Purification of chitinase from Trichoderma asperellum SH16 by polyethylene glycol/potassium phosphate aqueous two-phase system. Vietnam J Biotechnol 10(4A): 833-838.

63. Hoang Tan Quang, Hoang Thi Minh Hoa, Nguyen Thuy Lan Anh, Truong Thi Bich Phuong, Nguyen Hoang Loc (2012) Study on genetic diversity of some pummelo varieties (Citrus grandis (L.) Osbeck) in Vietnam. Vietnam J Biotechnol 10(4A): 977-984. 

64. Nguyen Hong Van, Hoang Tan Quang, Le My Tieu Ngoc, Nguyen Huu Nhan, Cao Dang Nguyen, Nguyen Hoang Loc (2013)Isolation and characterization of the carboxymethyl cellulase from Trichoderma asperellum. Proc the National Conference of Biotechnology. Natural Sciences and Technology Publishing House, Ha Noi 569-573.  

65. Hoang Tan Quang, Pham Thi Diem Thi, Truong Thi Bich Phuong, Nguyen Hoang Loc (2013) Study on genetic diversity of Thanh tra pummelo (Citrus grandis (L.) Osbeck) using SSR tool. Proc the National Conference of Biotechnology. Natural Sciences and Technology Publishing House, Ha Noi 1012-1016.

66. Nguyen Hoang Loc, Le My Tieu Ngoc, Doan Thi Tam, Hoang Tan Quang, Tran Thuy Lan, Le Quoc Viet, Phan Van Quyet, Dinh Thi Bich Lan, Phung Thang Long (2013) Cloning and expression of gene encoding 987P fimbrial subunit of enterotoxigenic Escherichia coli 13NT. Proc the National Conference of Biotechnology. Natural Sciences and Technology Publishing House, Ha Noi 132-136.

67. Nguyen Hoang Loc, Nguyen Thi Khanh Quynh, Hoang Tan Quang, Tran Thuy Lan, Le My Tieu Ngoc, Dinh Thi Bich Lan, Phung Thang Long (2014) Enhancing expression of recombinant fimbrial adhesin K88 isolated of enterotoxigenic Escherichia coli from piglet. Vietnam J Biol 36(1se): 120-125.

68. Hoang Tan Quang, Le My Tieu Ngoc, Nguyen Thi Quy Hoa, Nguyen Hoang Loc (2014) Enhancing the expression of 42 kDa chitinase from Trichoderma asperellum SH16 in Saccharomyces cerevisiae. Vietnam J Biotechnol 12(4): 715-721.  

69. Nguyen Huu Thuan Anh, Ton Nu Thuy An, Le Thi Ha Thanh, Vo Thi Vien Dung, Nguyen Thuan Nho, Dinh Hong Kim Cuong, Nguyen Ngoc Hieu, Nguyen Thanh Giang, Nguyen Hoang Loc (2015) Study on effect of methyl jasmonate and yeast extract on the growth and enhancement of solasodine biosynthesis in cell cultures of Solanum hainanense Hance. Vietnam J Biotechnol 13(2A): 513-519. 

70. Nguyen Thanh Giang, Hoang Tan Quang, Nguyen Duc Huy, Nguyen Huu Thuan Anh, Truong Thi Phuong Lan, Nguyen Hoang Loc (2015) Effect of elicitor on asiaticoside accumulation in centella (Centella asiatica (L.) Urban) cells. VNU Journal of Science 31(4S): 44-49.

71. Nguyen Thi Nhat Linh, Hoang Thanh Tung, Nguyen Hoang Loc, Duong Tan Nhut (2015) Enhancing secondary root formation and development from in vitro adventitious root of Ngoc Linh ginseng (Panax vietnamensis). Vietnam J Biotechnol 13(2): 221-230.

72. Nguyen Thi Nhat Linh, Hoang Thanh Tung, Nguyen Hoang Loc, Duong Tan Nhut (2017) The effect of biotic and abiotic elicitors on biomass and saponin production of secondary root cultivated in shake flasks Panax vietnamensis adventitious root. Vietnam J Biotechnol 15(1): 1-7.

73. Nguyen Thi Nhat Linh, Nguyen Hoang Loc, Duong Tan Nhut (2017) Application of elicitor for production of saponins from in vitro Panax cultures. Vietnam J Biotechnol (accepted).

C. Nucleotide and protein sequence data
See: National Center for Biotechnology Information (NCBI)

 D. Books

1. Nguyen Hoang Loc (2006) Cell Biotechnology. Hue University Publishing House, Hue, VN.
2. Nguyen Hoang Loc (2007) Introduction to Biotechnology. Hue University Publishing House, Hue, VN.
3. Nguyen Hoang Loc (ed), Tran Thi Le, Ha Thi Minh Thi (2007) Molecular Biology. Hue University Publishing House, Hue, VN.
4. Nguyen Hoang Loc (ed), Le Viet Dung, Tran Quoc Dung (2009) Recombinant DNA Technology. Ho Chi Minh City National University Publishing House, Ho Chi Minh City, VN.

5. Nguyen Hoang Loc (2011) Plant Tissue and Cell Culture: Concepts and Applications. Hue University Publishing House, Hue, VN.

6. Nguyen Hoang Loc (2013) Production of Some Pharmaceutical Compounds by Plant Cell Culture and Transgenic Plants. Hue University Publishing House, Hue, VN.

 

 

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(C) 2014 Department of Biotechnology

Address: Department of Biotechnology, College of Sciences, Hue University  

77 Nguyen Hue Street, Hue 47000, Vietnam. Tel: +84-54-6505051, Fax: +84-54-3824901, Email: biotech.hue@gmail.com